口腔粘膜良性淋巴组织增生病淋巴细胞性质的研究

The investigation on the character of lymphocytes in benign lymphoadenosis of oral mucosa

目的研究口腔粘膜良性淋巴组织增生病(benign lymphoadenosis of oral mucosa,BLOM)中增生的淋巴细胞的性质。方法采用免疫组化SP法检测14例口腔粘膜良性淋巴组织增生病、9例粘膜良性淋巴组织增生病伴上皮异常增生、11例口腔粘膜良性淋巴组织增生病发生癌变者及10例正常口腔粘膜组织中淋巴细胞CD20和CD45RO的表达。结果正常粘膜中有8例出现CD45RO阳性染色,且染色强度和阳性细胞数并不均一;未见CD20阳性染色。口腔粘膜良性淋巴组织增生病发生癌变组中有一例CD20阴性,其余各组均可见CD20和CD45RO阳性染色,细胞分布呈现出明显的规律性,CD20主要见于淋巴滤泡内或呈灶性聚集的淋巴细胞中,在周围的组织中阳性细胞较少,CD45RO则主要出现在固有层,淋巴滤泡内也可见部分阳性细胞。结论BLOM中浸润的淋巴细胞既有T细胞,亦有B细胞,属于多克隆增生。

Objective To study the character of lymphocytes in benign lymphoadenosis of oral mucosa（BLOM）.Methods The expression of SP immunohistochemical staining against CD20, CD45RO were evaluated in 14 cases of BLOM,9 BLOM with dysplasia, 11 carcinogenesis of BLOM and 10 normal oral mucosa.Results There was CD45RO positive staining in 8 out of 10 normal tissues and there was no CD20 positive staining in 10 normal tissues. There was CD20 negative staining in 1 out of 11 carcinogenesis of BLOM and there were simultaneously CD20 and CD45RO positive staining in all the other BLOM.Conclusion the lymphocytes of BLOM came from both T cell and B cell. This proved the lymphoid tissue in BLOM is mucosa-associated lymphoid tissue （MALT）, it is not a kind of lymphoma but a kind of proliferation disease.