阿立哌唑对女性首发和复发精神分裂症甲状腺激素、泌乳素的影响

Treatment effects of aripiprazole on thyroid hormones and prolactin in female schizophrenia

目的探讨阿立哌唑对女性精神分裂症住院患者甲状腺激素、泌乳素的影响及首发、复发病例的差异。方法随机抽取女性精神分裂症患者67例（首发26例，复发41例），均用阿立哌唑治疗，于治疗前和治疗2、4、8周末进行抽血检验甲状腺激素和泌乳素。结果阿立哌唑治疗2周末时，血清甲状腺素（T4）、血清泌乳素（PRL）有显著性差异。结论阿立哌唑短期使用（2周末）时可以降低患者血清甲状腺素（T4）、血清泌乳素（PRL）水平，而4-8周时则无明显差异；对三碘甲腺原氨酸（T3）、游离三碘甲腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺素（TSH）无明显差异；首发与复发病例无明显差异。

Objective： To explore effects on thyroid hormones and prolactin by aripiprazole in initial and recurrent female schizophrenia. Methods： 67 radomly chosen cases（26 were initial and 41 were recurrent cases） of female schizophrenia were treated with aripiprazole. Thyroid hormones and prolactin （PRL）were measured before and after 2,4,8 weeks of treatment respectively. Results： Serum thyroid hormone （T4） and prolactin（PRL） were significantly lower after 2 weeks of treatment. Conclusion ： Serum thyroid hormone （T4） and prolactin（PRL） were lower after short period （2 weeks） of treatment, while remain no difference after long term treatment（4 and 8 weeks）. Triiodothyronine （T3） , free triiodothyronine （FI3）, free serum thyroid hormone（FF4） and thyroid stimulating hormone （TSH） all remained unchanged. Initial and recurrent cases showed no difference.