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HLA-B27与强直性脊柱炎的免疫生物学发病机制研究进展 被引量：5

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摘要 脊柱关节炎（spondyloarhritis，SpA）是一组临床特征相似、均不同程度地与HLA—B27相关、发病机制互相关联的疾病，包括强直性脊柱炎（ankylosing spondylitis，AS）、反应性关节炎（reactive arthritis，ReA）、炎症性肠病相关关节炎、银屑病关节炎、幼年脊柱关节炎和未分化脊柱关节病（undifferentiated spondyloarthropathy，uSpA）。AS是SpA的原型，与HIA—B27关系最密切。1973年Schlosstein和Brewerton分别报道了HIA—B27与AS发病显著关联．
作者 吴震 古洁若
机构地区 中山大学附属第三医院风湿科
出处 《中华风湿病学杂志》 CAS CSCD 2007年第11期684-687,共4页 Chinese Journal of Rheumatology
基金 国家杰出青年基金(30325019)
关键词 强直性脊柱炎 发病机制 B27 HLA 免疫生物学 未分化脊柱关节病 脊柱关节炎 反应性关节炎
分类号 R593.23 [医药卫生—内科学]
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参考文献23

  • 1Hermann E, Yu DTY, Meyer zum Buschenfelde KH, et al. HLA- B27 restricted CD8 T cells from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet, 1993, 342: 646-650.
  • 2Smith JA, Marker-Hennann E, Colbert RA. Pathogenesis of ankylosing spondylitis: current concepts. Best Pract Res Clin Rheumatol, 2006, 20: 571-591.
  • 3Hacquard-Bouder C, htah M, Breban M. Animal models of HLA-B27 associated diseases:new outcomes. Joint Bone Spine, 2006, 73: 132-138.
  • 4Colbert RA. The immunobiology of HLA-B27:variations on a theme. Curr Mol Med, 2004, 4:21-30.
  • 5Boyle LH, Hill-Gaston JS. Breaking the roles: the unconventional recognition of HLA-B27 by CD4^+ T lymphocytes as an insight into the pathogenesis of the spondyloarthropathies. Rheumatology (Oxford), 2003, 42: 404-412.
  • 6Allen RL, O'Callaghan CA, McMichael AJ, et al. HLA-B27 can form a novel b2-microglobulin-free heavy chain homodimer structure. J Immunol, 1999, 162: 5045-5048.
  • 7Antoniou AN, Ford S, Taurog JD, et al. Formation of HLA-B27 homodimers and their relationship to assembly kinetics. J Biol Chem, 2004, 279: 8895-8902.
  • 8Malik P, Klimovitsky P, Deng LW, et al. Uniquely conformed peptide-containing β2-microglobulin-free heavy chains of HLA- B2705 on the cell surface. J Immunol, 2002, 169: 4379-4387.
  • 9Dangoria NS, DeLay ML, Kingsbury DJ, et al. HLA-B27 misfolding is associated with aberrant intennolecular disulfide bond formation (dimerization) in the endoplasmic reticulum. J Biol Chem, 2002, 277: 23459-23468.
  • 10Saleki K, Hartigan N, Lith M, et al. Differential oxidation of HLA-B2704 and HLA-B2705 in lymphoblastoid and transfected adherent cells. Antioxid Redox Signal, 2006, 8: 292-299.

二级参考文献25

  • 1Ikawa T,Ikeda M,Yamaguchi A et al.Expression of arthritis-causing HLA-B27 on Hela cells promotes induction of c-fos in response to in vitro invasion by Salmonella typhimurium [J].J Clin Invest,1998;101:263.
  • 2Hermann E,Yu D,Meyer Zum Buschenfelde K et al.HLA-B27 restricted CD8+T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis [J].Lancet,1993;342:646.
  • 3Colbert R.HLA-B27 misfolding:a solution to the spondyloarthropathy conundrum? [J].Mol Med Today,2000;6:224.
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  • 10Huang F,Hermann E,Wang J et al.A patient-derived cytotoxic T-lymphocyte clone and two peptide-dependent monoclonal antibodies recognize HLA-B27-peptide complexes with low stringency for peptide sequences [J].Infect Immun,1996;64(1):120.

共引文献12

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二级引证文献11

中华风湿病学杂志
2007年 第11期

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