两种结合雌激素对改善绝经期综合征的临床观察

Clinical observation of two kinds of conjugated estrogen in the treatment of menopausal symptoms

目的:观察比较结合雌激素片(试验组)与结合雌激素倍美力片(对照组)治疗绝经期综合征的疗效和安全性。方法:选取60例符合诊疗标准的患者随机分成试验组和对照组,每日服结合试验或对照药物1片,28天为1周期,第15～28天均添加安宫黄体酮片每日4mg,通过随机开放平行对照方法对两组潮热症状评分,Kupperman评分、血清E2水平、血脂的变化及不良反应发生情况比较。结果:两组治疗后,潮热症状评分及Kupperman评分均明显下降,血清雌二醇、甘油三酯(TG)和高密度脂蛋白(HDL-C)均升高,低密度脂蛋白(LDL-C)降低,组内比较(P<0.001),差异有统计学意义。组间等效性检验比较(P>0.05),无显著性差异。不良反应两组之间比较(P>0.05),无显著差异。结论:国产结合雌激素片和倍美力一样能有效、安全地治疗妇女绝经期综合征。

Objective：To compare the efficacy and the safety of conjugated estrogen（CE） in the treatment of menopausal with conjugated equine estrogen（Premarin）. Methods：According to the standards ,a total of 60 patients were randomly divided into 2 groups：CE group and Premarin group,a period of 28 days,and from 15 to 28 days plus medroxyprogesterone（MPA） 4 mg Daily.Treatment lasted for 3 periods. This randomly publicly parallel was adopted to compare the hot flashes symptom scores,serum level of estradiol,Kupperman measurement Index and serum lipid. Results：The scores of menopausal symptom,hot flash scores and the serum level of estradiol ascent. TG、HDL-C ascented and LDL-C were reduced after treatment with CE or Premarin（P 〈 0.001）,No significant differences were discovered between the two groups through equivalence margin（P 〉 0.05）. There are no significant differences between the two groups on side effect（P 〉 0.05）. Conclusion：CE is safe and effective in treatment of menopausal symptoms.