鼻咽癌转录组学研究的现状与进展

The Present and Advance in Transcriptomics of Nasopharyngeal Carcinoma

转录组学是一门在整体水平上研究某一时刻某一细胞中基因全部转录本种类、结构和功能及转录调控规律的学科,它为研究鼻咽癌不同发病阶段的分子机理和调控网络提供全新的手段.现简要介绍鼻咽癌不同发病阶段相关易感/抑瘤基因的分离鉴定及其功能研究,各阶段基因转录谱和转录调控网络的构建等方面的研究现状和进展.

Transcriptomics studies the variety, structure, function and regulation of all transcripts in a given cell and in a given time. It provides a novel procedure for revealing the molecular mechanism and regulatory network of different development stages ofnasopharyngeal carcinoma. The progress of isolation, identification and function study of tumor susceptibility/suppressor gene, gene transcription profiling and transcription regulatory networks have been introduced.