子痫前期患者血清尿酸水平与围产儿结局的关系

Relationship between serum uric acid of pre-eclampsia women and perinatal outcomes

目的探讨子痫前期患者血清尿酸水平与围产儿预后的关系。方法将228例子痫前期患者分为轻度子痫前期及重度子痫前期,并选择120例正常单胎妊娠孕妇作为对照。分析三组患者血压,尿酸,肌酐,尿素氮水平,并观察三组围产儿结局。结果1、子痫前期患者血清尿酸水平高于正常对照组,重度子痫前期患者血清尿酸水平高于轻度子痫前期患者,差异均具有显著性意义。2、随着尿酸水平的升高,新生儿体重,阿氏评分逐渐降低,S/D逐渐升高,IUGR,胎儿窘迫,新生儿窒息发生率逐渐升高。3、同一妊娠状态,随着尿酸水平升高,新生儿体重及阿氏评分降低,同一尿酸水平,随着子痫前期病情加重,新生儿体重及阿氏评分也降低。结论子痫前期患者血清尿酸水平升高,且与病情严重程度成正比。随着血清尿酸水平升高,围产儿不良结局增加。

Objective To observe the relationship between serum uric acid of pre-eclampsia women and perinatal outcomes. Methods 228 pre-eclampsia women were divided into two groups and 120cases with norreal pregnancy were sampled as controls. The blood pressure, serum uric acid, BUN, Cr, and perinatal outcomes were observed. Results 1. The level of serum uric acid in pre-eclampsia group was higher than in normal group and the level of serum uric acid in serve pre-eclampsia group was higher than in slight group. The difference is significant. 2. With the increasing of serum uric acid, infant weights, Apgar scores decreased, and S/ D, number of FGR. Fatal distress. Newborn asphyxia increased gradually. 3.With the increasing of uric acid at the same pregnancy, infant weights and Apgar scores decreased gradually, so as at the same uric acid with the increasing of pre-eclampsia. Conclusions Serum uric acid of the patients with pre-eclampsia increased, and the level was increasing as pre-eclampsia developed. With the increasing of serum uric acid, bad perinatal outcomes increased.