摘要
蛋白多肽类药物由于其在生物体内含量低、半衰期短和易受内源性物质干扰等特点而使其体内动力学的研究面临很多挑战。生物样品分析方法是进行药物体内动力学研究的基础。综述了研究蛋白多肽类药物体内动力学的常规分析方法:免疫学分析法、同位素标记示踪法、生物检定法和理化分析技术。展望了荧光标记近红外检测技术在蛋白多肽类药物体内动力学无损实时在位分析上的应用前景。
Kinetics studies of protein polypeptide drugs face many challenges because of their low content in organisms, short half-life and vulnerability to interference by endogenous substances. Biological sample arialyrical methods am the basis of pharmacokinetics research. The cormaonly used analytical methods by which we study protein peptide pharmacokinetics, such as immtmoassay, isotope label trace assay, bioassays and physicochemical analytical techniques were summarized. And the prospect of near-infrared fluorescent detection technology in nondestructive real-time analysis of protein and pepfide drugs in vivo kinetics were mentioned.
出处
《药学进展》
CAS
2007年第10期433-438,共6页
Progress in Pharmaceutical Sciences
关键词
蛋白多肽类药物
体内动力学
分析方法
荧光标记近红外检测技术
Protein polypeptide drug
In vivo kinetics
Analytical method
Near-infrared fluorescent detection technology