摘要
目的观察大剂量免疫球蛋白联合糖皮质激素治疗和免疫抑制剂治疗重症大疱性皮肤病的临床效果。方法重症大疱性皮肤病患者合剂采用大剂量免疫球蛋白联合糖皮质激素和免疫抑制剂治疗(A组,32例)与糖皮质激素和免疫抑制剂治疗(B组,29例),对比分析两组患者的临床效果、起效时间、皮损明显消退时间和住院时间。结果两组患者的临床效果、起效时间、皮损明显消退时间和住院时间间差别均有显著性意义(P<0.05)。结论大剂量免疫球蛋白联合糖皮质激素和免疫抑制剂较单纯应用糖皮质激素和免疫抑制剂治疗重症大疱性皮肤病起效快、临床疗效好。
Objective To observe the clinical therapeutic efficacy of high-dose intravenous immunoglobulin combining with corticosteroid and immunosuppressant in treatment of severe bullous dermatosis.Methods Totally 32 cases treated with high-dose intravenous immunoglobulin combining with corticosteroid and immunosuppressant therapy were compared with 29 cases treated with corticosteroid and immunosuppressant,the clinical therapeutic efficacy,responsive time,notable effect time and hospitalization time were analyzed.Results Between the two groups there were significant differences in clinical therapeutic efficacy,responsive time,notable effect time and hospitalization time（P〈0.05）.Conclusion The therapy of high-dose intravenous immunoglobulin combining with corticosteroid and immunosuppressant is fast in responsive time and of high clinical efficacy compared with that of only corticosteroid and immunosuppressant in treatment of severe bullous dermatosis.
出处
《中国全科医学》
CAS
CSCD
2007年第21期1778-1779,共2页
Chinese General Practice
