摘要
目的探讨餐前和餐后血浆Ｐ物质（ＳＰ）及胃动素（ＭＴＬ）浓度在慢性胃炎中医证型间的变化规律．方法慢性胃炎肝胃不和型１３例，脾胃虚寒型１０例，健康志愿者１０名，采用ＲＩＡ法检测餐前、餐后３０ｍｉｎ和１２０ｍｉｎ血浆ＳＰ（ｐｍｏｌ／Ｌ）和ＭＴＬ（ｎｇ／Ｌ）浓度．结果餐后血浆ＳＰ水平３组均增高．正常对照组餐后３０ｍｉｎ明显高于餐前（３９４２±５６３ｖｓ３４８３±５４５，Ｐ＜００５），餐后１２０ｍｉｎ降至接近餐前水平（３５９３±５６２）．脾胃虚寒组餐后３０ｍｉｎ升高较餐前无统计学意义（３８５６±６２６ｖｓ３５２１±５３８，Ｐ＞００５），餐后１２０ｍｉｎ也渐下降（３７１２±６０７）．肝胃不和组餐前ＳＰ水平（３６６６±５６４）略高于其余２组，餐后３０ｍｉｎ升高幅度较小（３９２２±６１４）而餐后１２０ｍｉｎ继续升高（４０６３±５５８，与餐前比Ｐ＜００５）．血浆ＭＴＬ的结果表明，Ｂ、Ｃ组餐前水平相近（分别为３５８４２±５９２６和３５１５７±６１２６），餐后有相似的变化（餐后３０ｍｉｎ分别为３８８５４±６２７６和３８９０３±６６１６；餐后１２０ｍｉｎ分别为３４６３８±?
AIM To investigate the possible role of abnormal substance P (SP) and motilin (MTL) release in response to meals in the pathogenesis of chronic superficial gastritis with different types according to the traditional Chinese medicine. METHODS Chronic superficial gastritis ( n =23) were divided into two groups: Gan pi incoordination (group A, n =13) and Piyangxu (group B), and 10 healthy volunteers served as controls (group C). Blood was obtained from every subject for measurement of plasma levels of SP and MTL by RIA before and 30 and 120 minutes after meals. RESULTS Basal plasma SP levels were higher in group A than in groups C and B. Plasma SP levels were significantly elevated in group C at 30 minutes, and in group A at 120 minutes after meals, whereas release of SP in group B was affected slightly by meals. Plasma MTL levels were of great variation before meals. Increased releases of MTL in response to meals were seen in all the three groups, but none of them was of great significance. Basal MTL levels and MTL release after meal were slightly higher in group A than in the other two groups. CONCLUSION Higher basal SP levels before meals, delayed and prolonged SP release after meals, together with slightly higher plasma MTL concentrations, are associated with gastrointestinal motility disorders, and may play an important role in the pathogenesis of chronic gastritis with Gan pi incoordination.
