牛磺酸对饲高脂饲料大鼠脂肪代谢及免疫作用的影响

STUDIES ON ADDITIONAL EFFECT OF TAURINE ON FAT METABOLISM AND IMMUNE ACTION OF RATS FED HIGH FAT DIET

给Ｗｉｓｔａｒ大白鼠饲喂高脂高胆固醇饲料，并添加不同剂量的牛磺酸，以研究牛磺酸的代谢效应，结果表明：试验中的自制高脂、高胆固醇饲料可以成功地诱导大鼠产生高胆固醇血症及动脉硬化。向大鼠日粮中添加１％牛磺酸可显著地降低血清中的甘油三脂、乳酸脱氢酶及磷酸肌酸酶的含量（Ｐ＜０．０１）。添加３％或５％的牛磺酸时，除能使血清中ＴＧ、ＬＤＨ、ＣＫ降低外，还使血清中高密度脂蛋白胆固醇、总胆固醇及动脉硬化指数显著下降（Ｐ＜０．０１）．且５％牛磺酸的添加效果优于３％；而白细胞计数及血清免疫球蛋白（ｌｇＧ）含量则显著升高（Ｐ＜０．０１），但两个添加剂量的作用效果无显著差异。

Wistar rats were used as animal models to study concentration of TC,HDL C,TG,LDH,CK,IgG in serum, and AI,WBC in blood. The results showed that the diet added 1% taurine significantly decreased the concentration of TG, LDH and CK in serum. 3%,5% taurine significantly decreased TC and increased HDL C in serum. WBC and lgG in rat serum could be increased significantly, but there was no significant difference between 3% and 5% taurine.