左卡尼汀联合硫氮酮治疗老年人不稳定型心绞痛疗效观察

Effect of a combination therapy with L-carnitine and diltiazem in the treatment of aged patients with unstable angina pectoris

目的:观察左卡尼汀联合硫氮酮治疗不稳定型心绞痛(UAP)的疗效。方法:将101例同期收治的老年UAP患者随机分为硝酸甘油组(31例)、左卡尼汀组(28例)及联合用药组(42例),其年龄、性别、病情等无显著差异(P>0.05)。3组均予阿司匹林、肝素、辛伐他汀等基础治疗,硝酸甘油组在此基础上予硝酸甘油10 mg静滴,1次/d;左卡尼汀组予左卡尼汀3.0 g静滴,1次/d;联合用药组予左卡尼汀2.0 g、硫氮酮30 mg静滴,1次/d。3组均连用10 d为一疗程。结果:治疗后左卡尼汀组和联合用药组心绞痛分级症状改善、心电图改善情况及临床症状总有效率分别为92.86%、71.43%、95.23%和89.29%、68.86%、92.85%,均显著高于硝酸甘油组的61.29%、35.48%、64.52,P均<0.05。结论:提示在常规治疗基础上,左卡尼汀联合硫氮酮治疗老年人不稳定型心绞痛可取得明显的效果。

Objective：To evaluate the curative effect of combined use of L-carnitine and diltiazem in aged patients with unstable angina pectoris （UAP）. Methods： 101 aged patients with UAP were randomly divided into nitroglycerin group （31 cases）, L-carnitine group（28 cases） and combined L-carnitine/diltiazem group （42 ca- ses）. Three groups were given elementary treatment with aspirin, heparin and simvastatin. Nitroglycerin group were treated with nitroglycerin, 10 mg iv drip qd; patients of L-carnitine group received L-carnitine,3.0 g, iv drip qd ; and patients of combined group were treated with dihiazem 30 mg, and L-cainitine 2.0 g, iv drip qd. Treatment course was 10 d. Results： The overall effective rates of of combined group and L-carnitine group, in- eluding 3 parameters like improving of angina class, electrocardiograph （ ECG ） and clinical symptom were 92.9%, 71.4% , 95.2% and 89.3% ,68.9%, 92.9%, which were significant higher than that of control group 61.3%, 35.5% and 64.5% （P 〈0.05）. Conclusion ： There was significant curative effect of L-carni- tine and diltiazem in aged patinets with UAP at the elementary treatment.