茶树油脂质体凝胶剂的体外透皮扩散研究

Study on Transdermal Diffusion Action of Tea Tree(Melaleuca alternifolia)Oil Liposomes Gel

本文采用Franz扩散池、离体鼠皮对茶树油(TTO)凝胶剂与TTO脂质体凝胶剂进行体外透皮扩散研究,分别考察不同时间点的体外透皮量、皮肤层滞留量,并对两种制剂的体外透皮规律进行拟合,得出规律方程。研究结果表明,TTO脂质体凝胶剂的体外透皮扩散的皮肤滞留量显着增加,是TTO凝胶的2.54倍,说明以脂质体为载体可对茶树油的经皮吸收起到很好的缓释作用,能有效提高其在局部炎症皮层组织中的药物浓度及停留时间,有望成为茶树油应用的新剂型。

To study the transdermal diffusion action of tea tree oil （TrO） liposome gel and TTO gel used Franz diffuse instrument and rats skin. The percutaneous penetration of TTO liposome gel and TTO gel at different time were compared and get the pereutaneous equation of TTO liposome gel. There was significant difference between the percutaneous action of the two preparations. The TTO liposome gel can improve significantly the cumulation quality in skin of TTO in the skin, reach 2.54 times. Liposome gel can be used as a cartier of TTO in the skin application that increases the cumulation quality in skin.