慢性心力衰竭患者血清IL-1β、TNF-α水平及临床意义

Serum Levels of IL-1β and TNF-α and its Clinical Significance in Patients with Chronic Heart Failure

目的探讨慢性心力衰竭患者血清白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)含量及其临床意义。方法慢性心衰组包括62例慢性心力衰竭患者,按心功能分级(NYHA)分为3组:Ⅱ级组20人,Ⅲ级组20人,Ⅳ级组22人,另设15例健康人作对照。血清TNF-α、IL-1β含量测定采用酶联免疫吸附法(ELISA)。结果慢性心力衰竭患者血清IL-1β、TNF-α显著高于健康对照组,慢性心力衰竭患者心功能分级组间血清IL-1β、TNF-α水平差异有统计学意义,心功能Ⅳ级组显著高于心功能Ⅱ级组、Ⅲ级组。结论慢性心力衰竭患者血清IL-1β、TNF-α水平的变化参与慢性心力衰竭致病机制,它们之间可能还有相互作用及影响,共同参与慢性心力衰竭的发病机制。

Objective To investigate concentrations of serum IL-1β and TNF-ctand evaluate its clinical significance in the patients with ehronie heart failure（CHF）. Methods 62 eases with CHF were divided into three groups aeeording to eardiae funetion（NYHA elassifieation） ：elassⅡ group（n =20） ,elass Ⅲ group（n =20） and class IV group（n =22）, Healthy eontrol group inelude 15 healthy volunteers, Serum eoneentrations of IL-1 βand TNF-αwere measured by enzyme-liked immune-absorbent assay （ELISA）, Results The serum levels of IL-1βand TNF-αin the patients with CHF were signifieantly higher than that in healthy eontrol group,and the serum levels of IL-1βand TNF-αin three graded groups aeeording to eardiae funetion were also significant differenee. Conclusions Changes of serum levels of IL-1βand TNF-αinn the patients with CHF play a role in the pathogenic mechanism of ehronie heart failure. They maybe interaet and influenee each other in the pathogenie mechanism of chronic heart failure.