低分子肝素治疗不稳定型心绞痛疗效与安全性观察

Efficacy and Safety of Low Molecular Weight Heparin for Unstable Angle Pectoris

目的观察低分子肝素钙治疗不稳定型心绞痛(UAP)的疗效及安全性。方法41例UAP患者随机分为A组(治疗组,21例)和B组(对照组,20例),治疗组在常规治疗基础上加用低分子肝素皮下注射,对照组采用常规疗法(阿司匹林、硝酸酯类、倍他乐克、ACEI、心肌营养药物等)。治疗1周,观察治疗前后心绞痛缓解程度,心电图变化,APTT、INR、PT变化,出血并发症。结果治疗组控制心绞痛总有效率达94.5%,明显高于对照组70.0%,差异有统计学意义(P<0.01)。除极少数有皮肤瘀斑外,未见其它出血并发症。结论低分子肝素治疗UAP疗效确切,安全可靠,不必监测凝血情况,可临床推广。

Objective To observe the efficacy and safety of low molecular weight heparin（LMWH） for unstable angle pectoris （UAP）. Methods 41 patients with UAP were divided into two groups randomly, LMWH were given within 7 days in group A （21 cases） based on the routine treatment. Group B （20 cases） as a control were treated with the routine treatment method（ medicines included： Aspirin, organic nitrates, Betaloc ,ACEI, et al）. The remission of chest pain, the changes of EKG, APT＇r, INR, and PT, and side effects were observed. Results Total effective rate was 94.5% in group A and 70.0% in group B. There was significant difference between two groups（ P 〈0.01 ）. No other hemorrhage complication was observed except some ecchymosis in group A. Conclusions LMWH is effective and safe for UAP,The detection of blood coagulation can be omitted. The method is worthy to be revered in clinic.