正常口腔黏膜和口腔鳞癌中人乳头瘤病毒感染率的研究进展

The study of HPV prevalence in normal oral mucosa and oral squamous cell carcinoma

黏膜高危型HPV-16、HPV-18感染是宫颈癌的主要致病因素,且与口腔鳞癌的发生密切相关,但目前对口腔鳞癌中HPV的感染率和亚型的分布尚不十分清楚。作者系统查阅了目前已经发表的有关HPV在正常口腔黏膜或口腔鳞癌中感染率和亚型分布的文献资料,对正常口腔黏膜、口腔鳞癌中人乳头瘤病毒的感染率的研究进展进行了综述。

Mucosal infection with high-risk human papiloma virus （HPV） types 16 and 18 is the cause of cervical cancer and might be a subset of oral squamous cell carcinoma （OSCC）, yet the prevalence and type distribution of HPV in oral SCC remained unclear. We systematically reviewed published studies of OSCC biopsies, which were employed to detect and genotype HPV through different methods .The aim of this investigation is to carry out a bibliographic review on the prevalence of HPV in OSCC and normal oral mucosa. Supported by Key Project of National Natural Science Foundation of China （Grant No.30630065）, Key Lab Project of Science and Technology Committee of Shanghai Municipality （Grant No.06DZ22026） and Shanghai Leading Academic Discipline Project （Grant No. Y0203）.