摘要
目的探讨使用大剂量(40 mg/d)和常规剂量(20 mg/d)辛伐他汀治疗2周后不稳定型心绞痛(UAP)患者血浆高敏C反应蛋白(hs-CRP)浓度的变化,分析短期强化降脂治疗对hs-CRP水平的影响。方法选取UAP患者76例,随机分为常规降脂组和强化降脂组,分别接受辛伐他汀20 mg/d和40 mg/d治疗,测定治疗前及治疗后1周、2周血脂[总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)]和hs-CRP水平。结果常规降脂组和强化降脂组治疗2周后TG、和HDL-C变化不明显,TC和LDL-C均呈下降趋势(TC:F=44.88,P<0.0001;LDL-C:F=32.92,P<0.0001),强化降脂组下降更明显常规降脂和强化降脂治疗后hs-CRP水平呈下降趋势(F=4.515,P=0.044),强化降脂组治疗2周后hs-CRP下降更明显。相关性分析显示治疗后血浆hs-CRP浓度的变化与同期血脂(TC、LDL-C、HDL-C、TG)水平的变化无显著相关性。结论短期辛伐他汀治疗可以明显降低TC和LDL-C,辛伐他汀40 mg/d强化降脂治疗效果更显著;强化降脂治疗可以使hs-CRP水平显著下降,但与血脂下降并不相关。
Objective To study the changes of plasma high-sensitivity C-reactive protein （hs-CRP） concentrations in the patients with unstable angina pectoris （UAP） after two-weeks＇ treatment with simvastatin 20 mg or 40 mg per day,and explore the influence of aggressive lipid-lowering therapy on hs-CRP in short term. Methods Seventy-six UAP cases were randomly divided into two groups to accept simvastatin 20 mg per day as routine lipidlowering group （ROU group, n =38）,or simvastatin 40 mg per day as aggressive lipid-lowering group （AGG group, n = 38） at the base of routine therapy. The concentrations of LDL cholesterol（LDL-C）, HDL-C, TC,TG and hs-CRP of all the patients were measured before and one week and two weeks after therapy. Results Both TC and LDL-C could be decreased by simvastatin （20 mg or 40 mg daily） therapy through two weeks （TC： F =44.88, P d0. 0001; LDL-C. F =32.92, P d0. 0001）. The plasma hs-CRP concentration had descendent trend in two groups（ F =4. 515, P = 0. 044）. And, hs-CRP had more significant decrease in AUG group than that in ROU group. The reduction of plasma hs-CRP concentration was not related to the change of plasma lipid level. Conclusion Simvastatin 40 mg may effectively reduce the plasma hs-CRP concentrations in UAP patients by two weeks independent on its effect for TC, HDL-C, LDL-C and TG.
出处
《临床荟萃》
CAS
北大核心
2007年第21期1523-1525,共3页
Clinical Focus
