2型糖尿病患者微量白蛋白尿与早期动脉硬化关系的研究

Relation between minim albuminuria and fore arteriosclerosis of patients of type 2 diabetic mellitus

目的探讨2型糖尿病患者微量白蛋白尿与早期动脉硬化的关系。方法90例2型糖尿病患者，根据尿白蛋白排泄率（UAER）分为3组，即DM-A组（UAER〈20μg／min），DM-B组（UAER20～200μg／min），DM-C组（UAER〉200μg／min），采用高分辨率的彩色多普勒超声波仪器测量各组2型糖尿病患者颈总动脉内膜-中层厚度（IMT），并与尿白蛋白量、病程、血糖、糖化血红蛋白（GHbA1c）、血压、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）进行多元相关分析。结果IMT在2型糖尿病3个组中差异有统计学意义（P〈0．05），其中DM-C组IMT高于DM-A和DM-B组（均P〈0．05），而DM-B组高于DM-A组（P〈0．05）；IMT与尿白蛋白量、病程、血糖、GHbA1c、血压、TG、LDL-C呈线性相关（r值分别为0．582、0．467、0．413、0．483、0．423、0．517、0．529，均P〈0．05）。结论伴微量白蛋白尿的糖尿病患者存在早期动脉硬化。

Objective To discuss the relation between minim albuminuria and fore arteriosclerosis of patients of diabetes mellitus（DM）. Methods Ninety patients of type 2 DM were divided into three groups according to urine albumin excretion rate（UAER）, group DM-A （UAER〈20μg/min）, group DM-B UAER （20 - 200 μg/min）, group DM-C（UAER〉200μg/min）. High-definition colorful ultrasonic Doppler instrument was used to measure the inter mediate thickness（IMT） of the carotid of patients of type 2 DM. IMT was analyzed comparing with other factors like urine albumin,disease course,blood sugar,glyeosylated hemoglobin A1c（GHbA1 c）,blood pressure,triglycerides（TG）, low-density lipoprotein cholesterol（LDL-C）. Results The IMT of the carotid of the patients of DM showed significant difference among three groups（ P 〈0.05） ,IMT of DM-C was higher than that of DM-B and DM-A（both P 〈0.05）, meanwhile,DM-B was higher than DM-A（ P 〈0.05）;IMT and the amount of urine albumin, diseases course, blood sugar,GHbAlc, blood pressure, TG, LDL-C were linearly related （ r = 0. 582, 0. 467,0. 413,0. 483, 0. 423, 0. 517, 0. 529,respectively,all P 〈0. 05）. Conclusion The patients of DM with mini albuminuria have fore arteriosclerosis.