藏药复方TKF对自发性2型糖尿病小鼠(KK-Ay小鼠)糖代谢的作用研究

A Study of TKF on hypoglycemic effect in KK-Ay mice

目的:研究藏药复方TKF对KK-Ay小鼠的降糖作用。方法:以C57BL/6 J小鼠作为对照组,KK-Ay小鼠随机分为模型组、TKF组(1.125、2.25、4.5g/kg)和格列本脲组5组,连续灌胃35天,检测小鼠体重、空腹血糖、口服糖耐量、血清胰岛素和血脂等指标。结果:TKF 2.25g/kg组从给药7天起即出现空腹血糖的降低,并在给药期间维持在一较低水平,给药35天时TKF各组血清胰岛素水平显著降低,2.25g/kg组血清甘油三酯亦明显降低。结论:TKF具有降低KK-Ay小鼠血糖、血脂和胰岛素水平,改善胰岛素抵抗的作用。

Objective： To study the hypoglycemic effect of TKF in KK-Ay mice. Methods： KK-Ay mice were divided into model group,TKF-treated group（ 1. 125,2.25,4.5 g/kg） and glibenclamide-treated group（0. 005g/kg） randomly and C57BL/6J mice were control group. The body weight, fasting blood glucose, oral glucose tolerance test, and the serum levels of insulin, triglyceride and total cholesterol were diterminded. Results： After fed with TKF （2.25 g/kg） for 7 days, fasting blood glucose were decreased significantly and maintained a low level during the period fed with TKF. After fed with TKF for 35 days, the serum levels of insulin and triglyceride were reducted. Conclusion： TKF has the effect to decrease the levels of fasting blood glucose, insulin and triglyceride and improve insulin resistance.