乙型肝炎疫苗及其佐剂的研究进展

Progress in the developments of hepatitis B vaccine and its adjuvants

乙肝疫苗接种是阻断乙型肝炎病毒(HBV)的传播,预防和控制乙型肝炎的有效方法。本文就乙肝疫苗的发展,尤其是通过改善佐剂以提高疫苗免疫原性的研究进展进行了综述,包括铝佐剂乙肝疫苗、新型铝佐剂乙肝疫苗、脂质体乙肝疫苗、粒细胞巨噬细胞集落刺激因子(Gm-CSF)佐剂乙肝疫苗、植物佐剂乙肝疫苗、免疫激活序列佐剂乙肝疫苗、微球投递佐利系统乙肝疫苗。

The inoculation of hepatitis B vaccine is an efficient solution to block off the prevalence of HBV, and prevent and control hepatitis B. Progress in the development of hepatitis B vaccine, especially the promotion of vaccine＇s immunogenicity by meliorated adjuvants, has been reviewed in this paper. We described the developments of aluminum-adjuvant hepatitis B vaccines, novel aluminum-adjuvant hepatitis B vaccines, hepatitis B vaccines formulated with liposomes, granulocyte-macrophage colony-stimulating factor （GM-CSF） as a adjuvant for hepatitis B vaccines, plant adjuvant based hepatitis B vaccines, immunostimulatory sequence mediated hepatitis B vaccines, and microspheres as a delivery adjuvant system for hepatitis B vaccines.