阿立哌唑治疗晚发精神分裂症的疗效观察及其对认知功能的影响

Effect of aripiprazole on late-onset schizophrenia and cognitive function

目的:探讨阿立哌唑与利培酮对晚发精神分裂症的疗效及安全性,并比较它们对认知功能的影响。方法:45例晚发精神分裂症患者随机分为阿立哌唑组与利培酮组,其中阿立哌唑组21例使用阿立哌唑10～30 mg·d^(-1),利培酮组24例使用利培酮3～4 mg·d^(-1),分别采用阳性阴性症状评定量表(PANSS)及药物副反应量表(TESS)进行疗效及安全性评定,并于治疗前后测定事件相关电位。结果:阿立哌唑组总有效率71.4%,利培酮组总有效率75.0%,两组间疗效无统计学差异(P>0.05)。治疗前两组患者的事件相关电位与正常对照组比较有统计学差异(P<0.05),治疗后两组患者的事件相关电位与正常对照组比较,差异均无统计学意义。不良反应量表(TESS)两组比较无统计学差异。结论:阿立哌唑与利培酮治疗晚发精神分裂症疗效相当,不良反应轻,且对认知功能影响轻微。

Objective： To investigate the effects of aripiprazole on late-onset schizophrenia and cognitive function in comparison with risperidone. Methods： Forty-five patients with late-onset schizophrenia were randomly divided into aripiprazole （n = 21 ） and risperidone （n = 24） groups. The dose of aripiprazole was 10 - 30 mg·d^-1 , and risperidone was 3 - 4 mg·d^-1 Positive and negative symptom scales （PANSS）, and treatment side-effect scales （TESS） were used to assess the efficacy and safety. Event-related potential was detected before and after treatment. Results： There was no significant difference in the total efficient rate between aripiprazole （71.4%） and risperidone （75.0%） groups （P 〉 0.05）. Comparing to the healthy subjects, there were both a significant difference in the event-related potentials （P 〈 0.05） in aripiprazole and risperidone groups before treatment, but no significant difference was found after treatment. TESS was also not significantly different between 2 groups. Conclusion： The effects of aripiprazole and risperidone on late-onset schizophrenia are not different. Both drugs have minor side-effects and little effect on cognitive function.