复感儿GH-IGF-I轴功能水平与中医证型相关性研究

Study on Correlation between Functional Level of GH-IGF-I Axis and TCM Syndromes of Recurrence

目的:探讨复感儿生长激素(GH)和胰岛素样生长因子I(IGF-I)轴(GH-IGF-I轴)功能水平与中医证型的相关性,为复感儿不同中医辨证分型提供客观的量化指标。方法:辨证分为肺脾气虚及肺脾气阴两虚两种证型,在非急性感染期采血,采用酶联免疫吸附法(ELISA)测定IGF-I、IGFBP-3,并分别与健康儿童对照。结果:两证型IGF-I、IGFBP-3水平相比较差异无显著性。结论:表明复感儿在非急性感染期GH-IGF-I轴功能水平未受到较影响,对中医辨证分型无指导意义。

Object ： Research the relationship between Growth Hormone - Insulin Growth FactorlSpindle （ GH - IGF - I Spindle） function of the RRTIchidren and TCM syndromes for providing measuring standard for the TCM differentiation and classification in children RRTI cases. Method： Classified all the definite RRTI children cases into two groups ： Lung - spleen - qi deficiency and Lung - spleen - qi - yin deficiency. Collected the blood sample in the non - acute infectious period, and then determined the IGF - I and IGFBP -3 concentrations in these samples by Enzyme -linked Immunosorbent Assay （ELISA）, and compare the data with those in normal children group respectively. Result ： There is no significant difference between these two syndromes groups on IGF - I and IGFBP - 3 concentrations. Conclusion： The GH - IGF - I Spindle function of RRTI children was not obviously affected in the non - acute infectious period. The function is no supportive signficance to the TCM classification of children RRTI.