摘要
量子点是一种半径小于或接近于激子玻尔半径，能够接受激发光产生荧光的半导体纳米颗粒。与传统的有机荧光染料相比，量子点的荧光强度和稳定性更高，标记之后荧光可持续时间更长，而且不会对组织细胞造成明显的伤害。量子点的这些特性使其在细胞的识别鉴定，细胞表面或内部大分子和亚细胞结构的定位，细胞中生物分子的相互作用等研究中具有广泛的用途。随着量子点技术的不断发展，可将其应用于多种疾病，尤其是肿瘤的诊断，而其毒性还需要进一步的研究。
Quantum dot is a kind of semiconductor nanocrystals with physical dimensions smaller than the exciton Bohr radius. It fluoresce when it accept an excitation light. Compare to traditional organic fluorescent dyes, the fluorescent intensity and stability of quantum dots is higher and the fluorescent duration is much longer. Quantum dots do not have known harm to tissues and ceils. These characteristics make quantum dots a very useful research tool for the identif/cation of cells, determining the localization and orientation of bio-molecules inside or outside cells and subcellular structure, as well as studying the interaction of molecules in cells. With the progress in technical development, quantum dots may be used in clinical diagnosis for several diseases, such as cancer. The cytotoxicity of quantum dots needs further in-depth research.
出处
《国际生物医学工程杂志》
CAS
2007年第5期310-314,共5页
International Journal of Biomedical Engineering
基金
教育部新世纪优秀人才支持计划资助项目（NCET-04-0669）
全国优秀博士学位论文作者专项资金资助项目（200464）
武汉市创新研究课题资助项目（20066002054）
关键词
量子点
分子成像
细胞成像
体内成像
细胞毒性
quantum dots （QDs）
molecular imaging
cellular imaging
in vivo imaging
cytotoxicity
