男性不育症患者精浆CRP和IL-1α水平检测的临床意义

Detection of CRP and IL-1α of Seminal Fluid in Patients with Male Infertility and Its Clinical Significance

目的:探讨男性不育症患者精浆C反应蛋白(CRP)和白细胞介素-1α(IL-1α)水平检测及临床意义。方法:收集123例男性不育症患者精液标本,均作精液常规检验,根据白细胞数(WBC)不同分为正常组、+组、++组、+++组和++++组;处理后的精浆采用免疫比浊法测定CRP,酶联免疫吸附法定量测定IL-1α。结果:精浆CRP、IL-1α水平随WBC水平的增加而递增。除正常组和+组、+++组和++++组间CRP结果比较无统计学意义(P>0.05)外,CRP和IL-1α在其他各组间比较,差异均有显著性(P<0.05);精浆CRP、IL-1α水平与WBC水平呈正相关。结论:CRP、IL-1α定量检查有助于诊断男性不育症患者生殖系感染和疗效观察。

Objective: To explore clinical significance of CRP and IL-1α of seminal fluid in patients with male infertility.Method: Seminal fluid were collected from 123 patients with male infertility, which divided into five groups according to different white cell counting.The level of CRP and IL-1α were deteded.Results: Analysis of five group data showed the level of CRP and IL-1α was increased as white cell counting increased. Inter-group comparison showed that from low level to high level, there were significant difference between each other except CRP level of group 1 and group 2, group 4 and group 5. There was positive correlation between seminal fluid leukocyte level and CRP and IL-1α. Conclusion: Quantitative detection of CRP and IL-1α of seminal fluid could help patients with male infertility clinical diagnosis and judgement of curative effect.