静脉麻醉药物、单胺化合物和逆行性遗忘的关系研究进展

Relationship between intravenous anesthetics,monoamines and retrograde amnesia

学习和记忆是大脑的重要功能。遗忘即不能记忆,可分为顺行性遗忘和逆行性遗忘静。人类对逆行性遗忘的研究已有100年以上的历史。静脉麻醉药物如咪唑安定和异丙酚可以产生逆行性遗忘,也可以导致单胺化合物多巴胺和5-羟色胺的改变,而单胺化合物的变化被证明与逆行性遗忘有关,这可能是某些静脉麻醉药物产生逆行性遗忘的机制。现就静脉麻醉药物、单胺化合物和逆行性遗忘三者之间关系的研究状况作一综述。

Learning and memory are important brain functions. Amnesia means loss of memory, which is divided into anterograde and retrograde amnesia. Intravenous administration of propofol or midazolam often induces retrograde amnesia in anesthetized patients, as well as with changes in dopaminergic and serotonergic activities. Changes in amount of monoamines have been proved to relate with retrograde amnesia, which may be the mechanism of propofol and midazolam anesthesia - induced retrograde amnesia. This article will review the relationship between intravenous anesthetics, monoamines and retrograde amnesia .