脊髓水平γ-氨基丁酸转运体参与痛觉信息传递的研究进展

Research advances in involvement of spinal GABA transporters in transmission of nociceptive information

γ-氨基丁酸(GABA)是哺乳动物中枢神经系统的重要抑制性神经递质,能快速被γ-氨基丁酸转运体(GAT)摄取,从而终止其抑制作用。GABA作用的程度和持续时间受到GAT的调节。GAT作为GABA能系统重要的组成部分,参与痛觉信息在脊髓水平的传递和慢性疼痛的发生与发展过程。

g- aminobutyric acid （GABA） is the main inhibitory neurotransmitter in mammalian central nervous system. The action of GABA is terminated by the rapid uptake through g - aminobutyric acid transporters （ GABA transporters, GATs）. GATs are key functional components of GABA transmission in nervous system to regulate the magnitude and duration of GABA action. Besides in central nervous system, GATs also distribute in peripheral tissue including spinal cord. Spinal GATs involves in the transmission of nociceptive information.