等效线图解法在药效学相互作用研究中的应用

Drug Interaction analysis with isobolograms

两种药物的药效学相互作用是协同还是拮抗通常是根据其联合应用时的药效强于还是弱于两药单独应用时的效应之和来定义的。效价强度比恒定的两药在等效线图解法中表现为线性的相加等效线,而效价强度比不恒定的两药则表现为非线性的相加等效线。建立正确的相加等效线是判断药物相互作用为协同还是拮抗的重要步骤。此文讨论了以上二种情况,并提供了一些计算所需的数学公式。

Synergism and antagonism are commonly defined as a greater or lesser pharmacological effect for a two - drug combination that what would be predicted for ＂no interaction＂ from the knowledge of the effects of each drug individually. For drugs with a constant relative potency, this leads to linear additive isoboles, whereas a varying potency ratio produces nonlinear additive isoboles. Determination of the additive isobole is a necessary procedure for assessing both synergistic and antagonistic interactions of the combination. Both situations are discussed and the mathematical formulas needed to distinguish these cases are provided.