文拉法辛与阿米替林治疗卒中后抑郁的对照分析

Venlafaxine vs.Amitriptyline for Poststrooke Depression:A Contrast Analysis

目的:观察文拉法辛与阿米替林治疗卒中后抑郁(PSD)的疗效及副作用。方法:50例PSD患者被随机分为文拉法辛组(25例)与阿米替林组(25例),疗程为6wk。治疗前及治疗后1、2、4、6wk,分别以汉密尔顿抑郁量表(HAMD)、副反应量表(TESS)评定。结果:文拉法辛组与阿米替林组显效率分别为88%、84%,2组无显著性差异(χ2=0.003,P>0.05);治疗后1、2wk末HAMD2组有显著性差异(P<0.05);文拉法辛组治疗后1、2、4、6wk末TESS总分均显著低于阿米替林组,2组有显著性差异(P<0.05)。结论:文拉法辛具有起效快、副作用小的优点,是治疗PSD较为理想的药物。

OBJECTIVE： To observe the curative effects and adverse effects of venlafaxine vs.amitrlptyline in the treatment of poststroke depression（PSD）. METHODS： 50 PSD cases were randomized to venlafaxine group （n = 25） or amitriptyline group（ n = 25） .The course of treatment for both groups was 6wk .Scores of depression were assessed by Hamilton＇s depression scale（HAMD） and adverse reactions were assessed by treatment emergent symptom scale（TESS） before treatment and at 1,2, 4, and 6 weeks after treatment. RESULTS：The responsive rate of venlafaxine group vs. amitriptyline group was 88% vs .84%, showing no significant differences between the two groups（X^2= 0. 003, P 〉 0.05） .However, there were significances between the two groups in HAMD scores at 1 and 2 weeks after treatment（P〈0.05） .The total TESS score in venlafaxine group was significantly lower than in amitriptyline group at 1,2, 4, and 6 weeks after treatment, showing significant differences between the two groups（P 〈 0.05） .CONCLUSION ：Venlafaxine has the advantages of rapid response and less adverse reaction,and it is an ideal drug for the treatment of PSD.