氯氮平对精神分裂症患者血糖和胰岛素水平的影响

Effect of Clozapine on Levels of Blood Glucose and Insulin in Patients with Schizophrenia

目的:研究氯氮平对精神分裂症患者血糖和胰岛素水平的影响。方法:63例氯氮平组治疗前后进行空腹血糖及胰岛素水平自身对照,并与64例对照组进行比较。对高血糖者检查胰岛细胞抗体(ICA)、胰岛素抗体(IAA)。结果:治疗8wk后,氯氮平组血糖较治疗前和对照组升高,有显著性差异(P<0.05);氯氮平组胰岛素水平较对照组降低,有显著性差异(P<0.05)。高血糖者ICA、IAA检查示阴性。结论:氯氮平易引起2型糖尿病。

OBJECTIVE： To study the effects of clozapine on blood glucose and insulin levels in schizophrenic patients. METHODS： This is a self-controlled study in which the levels of blood glucose and insulin in clozapine group（n ： 63） were compared before and after treatment, and which were compared with the levels in the control group（n ： 64） . Insular cellular antibody（ICA） and insulin autoantibody（IAA） were detected in patients with high level of blood glucose.RESULTS： After treatment for 8 weeks, the blood glucose level was increased in clozapine group as compared with the same group before treatment and the control group, showing significant differences（P（0.05）, however, the insulin level in clozapine group was decreased as against control group, showing significant differences（P （0.05） .Both ICA and IAA were negative in patients with high level of blood glucose.CONCLUSION：Clozapine is likely to induce type 2 diabetes.