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别嘌呤醇降低血尿酸水平以控制慢性肾病进展的研究 被引量：4

Allopurinol in Lowering Serum Uric Acid Level for the Delay of the Progression of Chronic Renal Disease
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摘要 目的：探讨用别嘌呤醇降低血清尿酸水平以控制高尿酸血症慢性肾病进展。方法：将47例慢性肾病合并高尿酸血症患者随机分为治疗组与对照组，治疗组在对照组抗高血压药治疗的基础上给予别嘌呤醇100-200mg·d^-1。或通常疗法治疗12mo。结果：治疗组血清肌酐水平较对照组低，肾功能恶化者较对照组明显下降（P〈0．05）。结论：别嘌呤醇可保护肾功能，安全、有效。 OBJECTIVE：To discuss the use of allopurinol for the reduction of serum uric acid level in patients with chronic kidney disease complicating hyperuricacidemia so as to delay the progression of chronic renal disease.METHODS：A total of 47 patients with chronic kidney disease complicating hyperuricacidemia were randomly divided into treatment group and control group： the treatment group was given allopurinol 100--200mg · d^-1 in addition to the antihypertensive therapy as adopted in the control group or the common therapy for 12 months.RESULTS ：As compared with the control group, serum creatinine level was lower and the rate of renal function deterioration was significantly decreased in the treatment group（P〈 0.05） . CONCLU- SION ：Allopurinol is a safe and effective therapy for the protection of renal function.
作者 刘进 盛丹
机构地区 泸州医学院附属医院肾内科 广州中医药大学
出处 《中国药房》 CAS CSCD 北大核心 2007年第32期2524-2525,共2页 China Pharmacy
关键词 尿酸 慢性肾病 别嘌呤醇 前瞻性研究 Uric acid Chronic renal disease Allopurinol Prospective study
分类号 R969.4 [医药卫生—药理学] R983.2 [医药卫生—药品]
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参考文献10

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共引文献22

同被引文献41

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引证文献4

二级引证文献31

中国药房
2007年 第32期

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