广州管圆线虫致病机制的研究进展

Pathogenic mechanism of Angiostrongylus cantonensis

广州管圆线虫是一种人兽共患寄生虫，幼虫侵入人体后可移至大脑，主要引起嗜酸性粒细胞增多性脑膜脑炎。其发病为幼虫移行，幼虫在颅部占位并释放代谢产物，基质金属蛋白酶与纤溶酶原活化因子的产生，嗜酸性粒细胞对神经细胞的毒害及超敏反应等多因素作用的结果。偶尔该虫也可侵犯眼球，眼球病变主要是免疫反应导致的损害。了解广州管圆线虫的发病机制，对该病的防治和诊断具有重要意义。

Angiostrongylus cantonensis mainly causes eosinophiliomeningitis or meningoencephalitis. Its onset relates migration of larves, which occupy foci in brain, release metabolite, induce matrix metalloproteinase and plasminogen activator, eosinophil＇s toxic damage to nerve cells and hypersensitiveness and so on. Larves may invade eyeball occasionally, causing eye damage by immune response. Understanding of its pathogenesis is of significance for prevention and cure of the disease.