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补肝养髓方对自发老年性痴呆模型认知功能的影响 被引量:4

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摘要 目的:观察补肝养髓方对自发老年性痴呆模型学习记忆功能的影响。方法:昆明种自发老年性痴呆(记忆障碍)小鼠,随机分为4组,即空白对照组、西药对照组、补肝养髓小剂量组、补肝养髓大剂量组,另设老年学习记忆正常组。分组给药,连续60天。用跳台实验(step-down test)检测学习记忆成绩。结果:补肝养髓法能显著改善自发老年性痴呆模型小鼠学习能力,并显著提高其记忆成绩,其作用呈现一定的量效相关关系。结论:补肝养髓方可显著改善自发老年痴呆模型小鼠的学习记忆障碍。
出处 《中国中医药科技》 CAS 2007年第6期446-447,共2页 Chinese Journal of Traditional Medical Science and Technology
基金 广东省优秀中青年专家科研目标责任项目No.98036 深圳市重大科技项目No.2005048
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  • 1Sadik K, Wilcock G. The increasing burden of Alzheimer disease. Alzheimer Dis Assoc Disord,2003; 17(3):75
  • 2Phinney AL, Horne P, Yang J, et al. Mouse medels of Alzheimer' s disease: the long and filamentous road. Neurol Res,2003;25(6):590
  • 3Ingram DK. Analysis of age - related impairments in learning and memory in rodent models. Ann N Y Acad Sci, 1985;444:312
  • 4Gallagher N. Animal models of memory impairment. Philos Trans R Soc, Lond B Biol Sci, 1997;352(1362) : 1711
  • 5Tkegamic S. Transplantation of ventral forebrain cholinergic neurons to the hippocampus ameliorates impairment of radial - maze learning in rats with AF64A treatment. Brain Res, 1991 ;548 : 137
  • 6Danks A M. Behavioral and anatomical consequencces of unilateral fomix lesions and administration of numodipine. Brain Res, 1991 ;557(1 - 2) : 3O8
  • 7Fischer W, Gage EH, Bjorklund A. Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats Eur J Neurosci, 1989; 1:34
  • 8Eichenbaum H. The hippocampus and declarative memory: cognitive mechanisms and neural codes. Behav Brain Res,2001 ;127(1 - 2) : 199
  • 9Wu Zhengzhi, Zhang Yongfeng, Yang Ming. Comparative Studies on the Effects of Tonlfying the Kindey, Replenishing the Essence and Relieving the Heart to the Chemical Model of Alzheimer' s disease in mice by Orthogonal Test. Proceedings of the First Annual International Conference and Exposition of Distinguished New Development in Chinese Medicine. In: International Modem Research on Traditional Chinese Medicine, Beijing: 1996: 426

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