期刊文献+

多巴胺系统与亨廷顿舞蹈病关系的研究进展 被引量:1

下载PDF
导出
摘要 多巴胺系统在中枢神经系统中具有重要功能,我们已经知道帕金森病与其功能障碍有关。现在越来越多的研究证明亨廷顿舞蹈病(HD)中也存在多巴胺系统功能障碍,特别是纹状体内突触后多巴胺受体的丢失,且突变huntingtin蛋白与多巴胺系统之间存在相互联系,本文就多巴胺系统与HD的关系做一综述。
出处 《国际神经病学神经外科学杂志》 2007年第5期481-484,共4页 Journal of International Neurology and Neurosurgery
基金 浙江省自然基金(j20060713)
  • 相关文献

参考文献20

  • 1Holmes A,Lachowicz JE,Sibley DR.Phenotypic analysis of dopamine receptor knockout mice; recent insights into the functional specificity of dopamine receptor subtypes.Neuropharmacology,2004,47(8):1117-1134.
  • 2David HN,Ansseau M,Abraini JH.Dopamine-glutamate reciprocalmodulation of release and motor responses in the rat caudate-putamen and nucleus accumbens of "intact" animals.Brain Res Rev,2005,50(2):336-360.
  • 3Huot P,Levesque M,Parent A.The fate of striatal dopaminergic neurons in Parkinson's disease and Huntington's chorea.Brain,2007,130(1):222-232.
  • 4Andrews TC,Weeks RA,Turjanski N,et al.Huntington's disease progression PET and clinical observations.Brain,1999,122(12):2353-2363.
  • 5Pavese N,Andrews TC,Brooks DJ,et al.Progressive striatal and cortical dopamine receptor dysfunction in Huntington's disease:a PET study.Brain,2003,126(5):1127-1135.
  • 6van Oostrom JCH,Maguire RP,Verschuuren-Bemelmans CC,et al.Striatal dopamine D2 receptors,metabolism and volume in preclinical Huntington disease.Neurology,2005,65 (6):941-943.
  • 7Kennedy L,Shelbourne PF,Dewar D.Alterations in dopamine and benzodiazepine receptor binding precede overt neuronal pathology in mice modelling early Huntington disease pathogenesis.Brain Res,2005,1039(1-2):14-21.
  • 8Yohrling GJ,Jiang GCT,DeJohn MM,et al.Analysis of cellular,transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology.Mol Brain Res,2003,119(1):28-36.
  • 9Bohnen NI,Koeppe RA,Meyer P,et al.Decreased striatal monoaminergic terminals in Huntington disease.Neurology,2000,54(9):1753-1759.
  • 10Ginovart N,Lundin A,Farde L,et al.PET study of the pre-and post-synaptic dopaminergic markers for the neurodegenerative process in Huntington's disease.Brain,1997,120(3):503-514.

同被引文献17

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部