环氧合酶-2和survivin在B细胞非霍奇金淋巴瘤中的表达及意义

Expression and clinical significance of COX-2 and survivin in B cell non-Hodgkin′s lymphoma

目的:探讨环氧合酶-2(COX-2)和survivin在B细胞非霍奇金淋巴瘤(B-NHL)中的表达及临床意义。方法:采用免疫组化SP法检测43例B-NHL(B-NHL组)和10例良性淋巴结病变组织(对照组)中COX-2和survivin的表达。结果:COX-2和survivin在B-NHL组中的阳性表达率分别为55.8%(24/43)和69.8%(30/43),与对照组相比差异具有显著性(分别P<0.05和0.01)。Ⅲ/Ⅳ期B-NHL患者COX-2蛋白的表达要高于Ⅰ/Ⅱ期患者(P<0.05)。Survivin的表达与B-NHL的组织病理学等级和国际预后指数具有相关性(P<0.05)。Spearman相关分析表明COX-2的表达与survivin的表达呈正相关(r=1.000,P=0.030)。结论:COX-2和survivin在B-NHL中表达上调,两者之间的阳性表达密切相关,表明COX-2和survivin在B-NHL的发生和发展中具有协同作用。

Objective To investigate the expression and clinical significance of COX-2 and survivin in B cell non-Hodgkin＇s lymphoma（B-NHL）. Method The expression of COX-2 and survivin in 43 cases of B-NHL and 10 cases of benign lymph node lesions were detected by immunohistochemical streptavidin-biotin peroxidase method. Results The expression rate of COX-2 and survivin in B-NHL was 55.8% （24/43） and 69.8%（30/43）, respectively, being significantly higher than that in control group（P 〈 0.05 or P 〈 0.01 ）. The expression of COX-2 in B-NHL patients with stage Ⅲ/Ⅳ was higher than that in patients with stage Ⅰ / Ⅱ（P 〈 0.05）. The expression of survivin was related with histopathologic grade and IPI of B-NHL （P 〈 0.05）. Spearman＇s correlation analysis showed COX-2 expression was positively correlated with survivin expression （r=1.000, P=0.030）. Conclusion The specific up-regulation of COX-2 and survivin in B-NHL and the positive correlation between expression of COX-2 and survivin shows that they have an synergistic effect in the development and progression of B-NHL.