390例闭经患者染色体核型分析及临床意义

Chromosome type and clinical analysise in 390 dysmenorrheas.

目的分析原发和继发闭经患者的染色体异常情况并探讨其临床意义。方法对妇科门诊和住院确诊为原发和继发闭经患者,年龄13～40岁抽取外周血培养,制备染色体,采用G显带或显带分析。结果原发和继发闭经患者共390人,染色体核型分析结果60例异常占15.4%;原发闭经患者有133例,核型异常患者47例占12.1%;继发闭经患者257例,核型异常患者13例占3.33%。结论人类细胞染色体异常导致临床的原发闭经和继发闭经已占有较大比重,通过染色体核型分析有助于诊断原发性和继发闭经,并指导母亲下次怀孕时最好做产前诊断及优生筛查。

Objective： To analyse the surfer＇s excrescent circumstance in chromosome who are original or aeeodng dysmenorrheas and inquiry its clinical meaning. Methods ： Confirmed original or secondary dysmenorrheas who eome from hospitalization or gynecology out- patient, 13 -40 age, take out peypheyal vein blood to eultuve, the chromosome was prepared, the G -show or show band was analysed. Results： Original or secondary dysmenorrheal suffer totally 390, the 60 examples is of chromosome type abnormalng seendng which oceupids 15.4% ; the original dysmenorrheal is 133 example, chromosome type adnormalitg is 47 eoses which occupies 12. 1% ; The seeondarg dysmenorrbeal is 157 example, chromosome type abnormality is 13 examples which occupies 3. 33%. Conclusion： The human cell chromosome abnormal causes clinical original or secondary dysmenorrheal, is already of highly natio. This text discovers from the chromosome abnormality, a lot of mother pregnancy mid - term have the medicine that take over the sex hormone or touch with the environment which result the chromosome mutation. The ehnomosome diagnosis will guide the mother at another time preguaney had better to the prenatal period examines or take the embryo cheek.