孕妇凝血功能检测的临床意义

Clinical significance of examination of coagulation function in pregnant women

目的:研究凝血因子Ⅷ活性(Ⅷ:C)、纤维蛋白原(FIB)、D-二聚体(D-D)、凝血因子Ⅴ活性4项血凝指标在妊娠中的变化,探讨其在DIC诊断和预防中的价值。方法:凝血因子Ⅷ活性(Ⅷ:C)、纤维蛋白原含量(FIB)、血浆D-二聚体(D-D)、凝血因子Ⅴ活性测定共3815例(正常非孕妇女314例,正常孕妇3121例,其中DIC患者16例)。结果:DIC和正常孕妇与正常非孕妇女凝血因子Ⅷ活性(Ⅷ:C)、凝血因子Ⅴ差异有统计学意义(P<0.05);FIB、D-D正常孕妇均明显高于正常非孕妇女(P<0.05),并且DIC明显高于正常孕妇(P<0.001)。结论:产前凝血功能检测对预防和治疗DIC的发生和发展有着重要意义。

Objective： To study the level and clinical significance of factor Ⅷ, fibrinogen and D - dimer in pregnancy. Methods： 16 women with DIC, 3 815 normal pregnancy and 314 non - pregnancy women were studied. Results： Factor Ⅷ, fibrinogen and D - dimer activities of women with DIC of pregnancy and normal pregnancy were lower than that of non - pregnancy women （ P 〈 0. 05 ）. Fibrinogen and D - dimer with non - pregnancy women were significantly lower than that of DIC of pregnancy and normal pregnancy. Conclusion： Ante natal examination of coagulation function of high value in prevention and treatment of DIC of pregnancy.