冠周康口服液制备工艺研究

Study of Preparation Technology of Guanzhoukang Oral Liquid

目的探讨冠周康口服液的最佳提取工艺。方法本试验采用4因素3水平正交设计法,以组方中的龙胆苦苷含量、出膏率为指标,筛选影响冠周康口服液水提醇沉工艺的因素。结果冠周康口服液中龙胆草、板蓝根、黄芩采用乙醇提取,以龙胆苦苷含量为考察指标,最佳提取工艺条件为:乙醇提取浓度为65%,用量为药材总量的8倍,提取时间为1h,提取次数为3次。其余药物采用水煎煮提取,以出膏率为考察指标,最佳提取工艺条件为:水用量为药材总量的12倍,浸泡时间为0.5h,煎煮时间为每次1h,提取次数为3次。结论试验结果为确定冠周康口服液的制备工艺提供了实验依据。

Objective To establish the best technological condition of Guanzhoukang Oral Liquid. Method Based on the evaluation marker of extraction amount and gentiopicroside content in prescription, the factors influencing the effect of water decoction and alcohol reflux procedure were selected by orthogonal design. Results The best technological condition of Guanzhoukang Oral Liquid should be as follows： radix gentianae, radix isatidis and radix scutellariae contained in prescription were extracted by alcohol in which the concentration was 65%, 8 times of total amount of material herb, extracted 3 times, 1 h for each time. The left material herbs were extracted by water decoction in which amount was 12 times of total amount of material herb, soaked for half hour and decocted 3 times, 1 h for each time. Conclusion The result provides experimental basis for the preparation technology of Guanzhoukan Oral Liquid.