摘要
目的优选大蒜油β-环糊精(β-CD)包合物缓释片处方,制备中药挥发油固体缓释制剂。方法以大蒜油中有效成分大蒜素的释放度为指标,采用正交设计法优化缓释片的制剂处方工艺。结果优化所得处方为羟丙基甲纤维素9%,乳糖15%,聚维酮10%,微晶纤维素10%。以此处方制备的大蒜油β-CD包合物缓释片在体外可缓释8h。结论优化所得处方合理稳定,缓释片达到了缓释效果。
Objective To optimize the formulation of the Garlic off β-CD sustained-release tablet. Methods The preparation formulation of the sustained-release tablet was optimized by orthogonal design which took the released rate as the index. Result The optimized formulation contained 9% HPMC, 15% lactose, 10% PVP, 10% microcrystalline cellulose. The ingredient of Garlic oil sustained-release tablet by this formulation was released slowly in 8 h. Conclusion The optimized formulation is rational and stable, the tablet could be released slowly.
出处
《中国中医药信息杂志》
CAS
CSCD
2007年第11期54-55,共2页
Chinese Journal of Information on Traditional Chinese Medicine
基金
黑龙江中医药大学校基金课题(200136)
关键词
大蒜油β-环糊精包合物缓释片
正交设计
制备工艺
Garlic oil β-CD sustained-release tablet
orthogonal design
preparation technology
