蝮蛇抗栓酶与川芎嗪加维脑路通治疗急性脑梗塞的疗效比较

Comparison on therapeutic efficacy of ahylysantinfarctase and tetramethylpyrazine add venoruton in treating acute cerebral infarction

目的：比较蝮蛇抗栓酶与川芎嗪加维脑路通治疗急性脑梗塞的疗效。方法：将７０例急性脑梗塞患者随机分为２组，Ａ组４８例用蝮蛇抗栓酶０．５Ｕ溶于生理盐水２５０ｍｌ中静滴，每日１次；Ｂ组２２例用川芎嗪１２０ｍｇ加维脑路通４００ｍｇ溶于５％葡萄糖５００ｍｌ中静滴，每日１次。疗程均为２０天。结果：临床总有效率Ａ组为９３．７５％，Ｂ组为９５．４５％，２组总有效率比较无显著性差异（Ｐ＞０．０５）；显效率Ａ组（５２．０８％）优于Ｂ组（３６．３６％）。２组血液流变学各项指标的变化除纤维蛋白原和血小板粘附率Ａ组较Ｂ组下降明显外，大多无明显差异（Ｐ均＞０．０５）。结论：川芎嗪加维脑路通与蝮蛇抗栓酶都是治疗急性脑梗塞的有效药物；蝮蛇抗栓酶疗效优于川芎嗪加维脑路通，但其禁忌证较多。

Objective:To compare the efficacy of ahylysantinfarctase and tetramethylpyrazine add venoruton in treatment of acute cerebral infarction.Methods:Seventy cases of acute cerebral infarction were divided into two groups randomly:48 cases were treated with ahylysantinfarctase 0 5 U in normal saline 250 ml by intravenous drip (group A) per day and 22 cases were treated with tetramethylpyrazine 120 mg add venoruton 400 mg solving in 5% glucose 500 ml by intravenous drip per day.Twenty days as a therapy course.Results:The total effective rate was 93 75% in group A and 95 45% in group B respectively.There was no obvious difference between group A and group B( P >0 05),while the responsive rate of group A(52 08%)was superior to group B(36 36%).There was no obvious change on hemorrheologic parameters between the two groups except the level of fibrinogen and platelet aggragation rate were significantly decreased in group A,but not in group B.Conclusions:Ahylysantinfarctase and tetramethylpyrazine add venoruton both are effective drugs for treating acute cerebral infarction.In addition,ahylysantinfarctase may have more efficient and more contraindication in clinical practice.