摘要
目的:观察普乐林注射液(主要成分为葛根素)对心肌缺血的治疗及改善作用。方法:选择102例冠心病稳定型心绞痛患者,应用普乐林注射液50mg静滴治疗,每日1次,10日为1个疗程。30例患者治疗前后分别进行24小时动态心电图检查,20例患者治疗前后分别行运动平板试验检查。结果:治疗后显效15例,有效66例,总有效率为79.41%;治疗后30例患者24小时动态心电图ST段最大压低值明显减小〔治疗前为(2.97±1.16)mm,治疗后为(1.34±0.89)mm,P<0.01〕,20例运动平板试验检查患者治疗后缺血型ST段改变出现时间明显延长〔治疗前为(3.76±1.78)分钟,治疗后为(5.89±1.87)分钟,P<0.01〕,治疗后缺血型ST段改变恢复时间缩短〔治疗前为(9.86±1.38)分钟,治疗后为(6.27±1.42)分钟,P<0.05〕。结论:普乐林注射液对冠心病稳定型心绞痛患者有较好的治疗作用,并可增加患者的运动耐受性。
Objective:To observe the effect of “pu le lin” injection,puerarin)on treating and improving myocardial ischemia.Methods:One hundred and two cases of stable angina pectoris of coronary heart disease (CHD) were treated with “pu le lin” injection 50 mg intravenously per day and 10 days as one therapy course.The Holter examination was made for 30 cases and exercise stress test was made for 20 cases before and after treatment.Results:Fifteen cases were improved significantly and 66 cases were improved after treatment.The total effective rate was 79 41%.The maximum STsegment depression of Holter was decreased obviously (2 97±1 16)mm to (1 34±0 89)mm, P <0 01 ,the appearing time for ischemic STsegment change was delayed after treatment in exercise stress test (3 76±1 78)min to (5 89±1 87)min ,the restorative time of ischmic STsegment was shorten (9 86±1 38)min to (6 27±1 42)min, P <0 05 .Conclusions:There is a better therapeutic effect of “pu le lin” injection for patients with stable angina pectoris of CHD and it can enhance the movement tolerance.