摘要
目的：观察生脉注射液对缺血性心脏病患者心脏功能的影响。方法：４８例缺血性心脏病患者静滴生脉注射液２５～３０ｍｌ，每日１次，连用２周，治疗前后分别测常规导联心电图、血脂及心脏功能各参数。结果：生脉注射液对缺血性心脏病患者心电图ＳＴＴ的改变有恢复作用（８５％），并有一定的降血脂作用（Ｐ＜０．０５）；对心脏功能左室射血时间（ＬＶＥＴ）、射血前期（ＰＥＰ）、射血分数（ＥＦ）、等容收缩期（ＩＣＴ）、心搏出量（ＳＶ）、心输出量（ＣＯ）、冠状动脉灌注压（ＣＡＰ）、心内膜下心肌存活率（ＥＶＲ）、心缩力指数（ＨＩ）、心搏指数（ＳＶＩ）和心脏指数（ＣＩ）均有显著影响（Ｐ均＜０．０５）；心电图ＳＴＴ改变与等容舒张期（ＩＲＴ，ｒ＝－０．３８）、ＬＶＥＴ（ｒ＝０．６６）、ＥＶＲ（ｒ＝－０．６２）、ＣＡＰ（ｒ＝－０．５１）和ＣＩ（ｒ＝－０．２７）均具有相关性（Ｐ均＜０．０５）。结论：生脉注射液能增强心肌收缩力，改善心肌顺应性与协调性，提高冠状动脉灌注压及心肌存活率，提高ＥＦ与ＣＩ，对缺血性心脏病患者不失为是改善心脏功能的有效药物之一。
Objective:To observe the effect of “sheng mai” injection on cardiac function of patients with ischemic heart disease(IHD).Methods:Fortyeight cases of IHD were treated with “sheng mai” injection 25￣30 ml per day for 2 weeks.The routine ECG,plasma lipids (PL) and some parameters of cardiac function were measured before and after treatment.Results:There was a restorative action for STT change (85%) and PL level was lower after treatment ( P <0 05).In addition,it could influence certain cardiac function,such as left ventricular ejection time(LVET),preejection period (PEP),ejection fraction(EF),isovolumetric contraction time(ICT),stroke volume (SV),cardiac output(CO),coronary artery perfusion pressure(CAP),endomyocardium survival rate (EVR),heart contraction index(HI),stroke volume index(SVI) and cardiac index(CI) (all P <0 05).On the other hand,there were correlation between the change in STT of ECG and isovolumetric relaxation time(IRT, r =-0 38),LVET( r =0 66),EVR( r =-0 62),CAP( r =-0 51),CI( r =-0 27),all P <0 05.Conclusions:“Sheng mai” injection can enhance myocardial contractility,improve myocardial complicance and synergy,elevate coronary perfusion pressure,myocardial survival rate,EF and CI.Therefore,“sheng mai” injection is an effective drug for improving cardiac function.
