肠易激综合征血浆及乙状结肠粘膜中CCK及SP的含量

Cholecystokinin and substance P of the plasma and sigmoid mucosa in irritable bowel syndrome

目的探讨胆囊收缩素（ＣＣＫ）、Ｐ物质（ＳＰ）在肠易激综合征（ＩＢＳ）疾病过程中的可能作用和临床意义．方法应用放射免疫分析法检测正常组２４例及ＩＢＳ组２６例受检者血浆及乙状结肠粘膜中ＣＣＫ和ＳＰ的含量．结果ＩＢＳ患者血浆ＣＣＫ含量（５０６ｐｍｏｌ／Ｌ±２９８ｐｍｏｌ／Ｌ）明显高于正常组（３０８ｐｍｏｌ／Ｌ±２１４ｐｍｏｌ／Ｌ）（Ｐ＜００５），ＳＰ的含量两组无显著差别（Ｐ＞００５）；乙状结肠粘膜中ＣＣＫ和ＳＰ的含量两组无显著差别（Ｐ＞００５）．结论血浆ＣＣＫ在ＩＢＳ的疾病过程中可能起有一定的作用，可作为ＩＢＳ的诊断标志；ＳＰ对ＩＢＳ可能无重要意义．

AIM To investigate the possible role and clinical significance of the cholecystokinin (CCK) and substance P (SP) in the irritable bowel syndrome (IBS). METHODS The CCK and SP of the plasma and sigmoid mucosa were measured by the radioimmunoassay in the normal group ( n =24) and the IBS group ( n =26). RESULTS The plasma CCK in the IBS group was significantly higher (5 06pmol/L±2 98pmol/L vs 3 08pmol/L±2 14pmol/L) than that in the normal group ( P <0 05), while the plasma SP and the CCK and the SP of the sigmoid mucosa had no significant differences ( P >0 05) between the two groups. CONCLUSION The plasma CCK may play a role in the IBS process and may be of potential diagnostic value, while the SP in plasma and sigmoid mucosa is of no great significance in IBS.