丘脑出血伴消化道出血患者血清胃液素的变化

Serum gastrin level changes in patients with thalamic hemorrhage complicated with GI tract bleeding

目的探讨丘脑出血伴消化道出血与血清胃液素的关系．方法采用放射免疫方法检测丘脑出血患者２８例（男１６例，女１２例），分为急性期与恢复期及伴消化道出血１２例，伴或不伴消化道出血１３例的血清胃液素，并与３０例正常人对照．结果丘脑出血患者的胃液素水平为２０１０ｎｇ／Ｌ±７５１ｎｇ／Ｌ，较正常对照组（８１０ｎｇ／Ｌ±４７２ｎｇ／Ｌ）明显升高，其中急性期伴消化道出血（２２４０ｎｇ／Ｌ±６８８ｎｇ／Ｌ）或不伴消化道出血（１６４１ｎｇ／Ｌ±７１１ｎｇ／Ｌ）患者的胃液素水平与正常对照组之间也分别具有统计学差异．结论胃液素的改变与丘脑出血有关，尤其是急性期和伴消化道出血患者明显增高．

AIM To study the relationship between thalamic hemorrhage with digestive tract bleeding and serum gastrin levels. METHODS The serum gastrin levels were measured by radio immunoassay in 28 patients with thalamic hemorrhage (16 males and 12 females; 13 with GI tract bleeding, 12 without GI tract bleeding) and 30 healthy controls. RESULTS The serum gastrin levels in patients with thalamic hemorrhage were increased significantly compared with that in controls (201 4ng/L±75 1ng/L vs 81 0ng/L±47 2ng/L, P <0 01). There were also statistically significant differences between the acute patients, the patients with (224 0ng/L±68 8ng/L) or without gastrointestinal tract bleeding (164 1ng/L±71 1ng/L) and the controls. CONCLUSION The changes of serum gastrin levels are associated with thalamic hemorrhage, especially in the acute patients and the patients with gastrointestinal tract bleeding.