Survivin蛋白在早期非小细胞肺癌中的表达及其与预后的关系

Expression and Prognostic Value of Survivin Protein in Early-stage Non-small Cell Lung Cancer

背景与目的:Survivin作为凋亡蛋白抑制家族成员,在多种肿瘤组织中出现高表达。本实验研究Survivin蛋白在早期非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达及其预后意义。方法:用免疫组化染色方法检测213例NSCLC的肿瘤组织中Survivin蛋白的表达,并采用Kaplan-Meier法进行单因素生存分析,用Cox比例风险模型进行多因素分析。结果:NSCLC组织中免疫组化染色Survivin阳性细胞百分率>10%者193例(90.6%);Survivin蛋白低表达(≤75%)170例,高表达(>75%)43例。Survivin蛋白在细胞核与细胞浆内均有表达。多因素Cox比例风险模型显示Survivin蛋白表达无预后意义(P>0.05),肿瘤直径≤3cm的肺小腺癌组生存曲线提示Survivin蛋白低表达组与高表达组比较具有生存优势,但两者之间的差异无统计学意义(P>0.05)。结论:早期NSCLC中Survivin蛋白表达的预后意义尚不明确。

BACKGROUND ＆ OBJECTIVE： As a member of the inhibitor of apoptosis （lAP） family, Survivin is highly expressed in various cancers, and is considered as an indicator of poor prognosis. This study was to investigate the expression and prognostic value of Survivin in early-stage nonsmall cell lung cancer （NSCLC）. METHODS： The expression of Survivin in 213 specimens of NSCLC was detected by immunohistochemistry. Patients＇ survival was analyzed by Kaplan-Meier method. The prognosis was analyzed by Cox multivariate model. RESULTS： Survivin was expressed in both nuclei and cytoplasm. Of the 213 patients, 170 （79.8%） had low expression of Survivin （positive rate of ≤75%）, 43 （20.8%） had high expression of Survivin （positive rate of 〉75%）. Cox analysis showed that the expression of survivin was an independent predictor of overall survival （P〉0.05）. Among the 39 patients with small lung adenocarcinoma （tumor diameter of 〈3 cm）, the difference in survival between Survivin-positive and Survivin-negative groups was not significant （P〉0.05）. CONCLUSION： The prognostic value of Survivin in early-stage NSCLC is unclear.