关节康口服液对大鼠佐剂性关节炎的治疗作用及胃黏膜保护作用研究

Research on Clinical Treatment Effect of Arthrosis Healing Oral Liquor on Osteoarthritis and Stomachic Mucosa Protection

目的评价关节康口服液对疼痛性关节炎的疗效和安全性。方法采用弗氏完全佐剂制备大鼠佐剂性关节炎(AA)模型,观察关节康对AA大鼠的治疗作用和胃肠保护作用。结果关节康口服液不仅能抑制AA大鼠的原发性炎症,而且对继发性炎症也有抑制作用,对胃黏膜的损伤程度也远小于英太青(P<0.01)。结论关节康口服液对AA有较好的治疗作用,且对胃黏膜具有一定的保护作用。

Objective To study the effect and safety of Arthrosis Healing Oral Liquor（AHOL） in curing aching arthritis. Methods Complete Freund＇s adjuvant（CFA） was adopted in rat adjuvant arthritis, AA model, to observe the therapeutic effect and protective effect of AHOL on gut in AA rat, and to compare with the group taking Yingtaiqing. Results No obvious difference existed in the effect of anti-inflammation and pain-reliveing between the AHOL group and the control group. AHOL played the inhibitory function on essential inflammation and secondary inflammation on AA rat, and has obviously inhibitory function to rat synovial membrane PGE2, but with no obvious influence on stomachic mucosa PGE2. Conclusion AHOL has good therapeutic effect on rat adjuvant arthritis and certain protective effect on stomachic mucosa.