焦作市中小学生乙型肝炎免疫效果调查

STUDY ON THE EFFECT OF IMMUNOREACTION OF HEPATITIS B VACCINE ON STUDENTS OF JIAO ZUO CITY

[目的]调查焦作市城乡中小学生乙型肝炎的免疫效果,为防治乙型肝炎提供科学依据。[方法]采用整群分层随机抽样的方法从焦作市城乡确定调查对象1906名,应用酶联免疫法检测乙肝表面抗原(HBsAg),乙肝表面抗体(抗-HBs),乙肝核心抗体(抗-HBc)。[结果]市区乙肝接种率为98.89%高于农村的96.62%,抗-HBs阳性率平均为58.50%,HBsAg阳性率为2.62%,抗体无应答率为9.54%。[结论]乙肝疫苗效果显著,需加强农村地区的接种工作。对于无应答者,我们应该采取有效手段以提高他们的乙肝免疫水平。

To investigate the effect of the hepatitis B vaccine on students and provide scientific evidence for preventing it.[Methods]A randomized sampling survey was carried out. A total of 1906 children,selected in four schools （two from elementary schools and two from junior high schools） from both city and countryside.[Results]The HB vaccine coverage rate in the city schools （98.89%） was higher than that in countries （96.62%）. The anti-HBs positive rate was 58.5% in average and the HbsAg carrier rate was 2.62%. The non-response rate was 9.54% in average.[Conclusion]It suggests that the effect of hepatitis B vaccine was obvious,but the vaccination program should be strengthened in the countryside. To people with non-response,we should take measures to improve immunization level of anti-hepatitis B virus among them.