多巴胺和纳洛酮治疗新生儿缺氧缺血性脑病

DOPAMINE AND NALOXONE FOR THE TREATMENT OF NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY

[目的]观察应用小剂量多巴胺和纳洛酮治疗新生儿缺氧缺血性脑病(HIE)的临床效果。[方法]91例HIE患儿随机分为2组,对照组45例给予吸氧,对症和支持等常规治疗,观察组46例在常规治疗基础上早期应用多巴胺5μg/kg/min,持续静脉滴注,纳洛酮0.1mg/kg.d加入10%葡萄糖溶液30ml静脉滴注,一日一次,连用7d。[结果]观察组显效31例,有效15例,总有效率100%,对照组显效7例,有效26例,无效12例,总有效率73.3%。观察组总有效率明显高于对照组(P﹤0.05)。[结论]应用小剂量多巴胺和纳洛酮治疗新生儿缺氧缺血性脑病可缩短疗程,降低病死率,改善预后。

To observe the clinical effects of low dosage of dopamine and naloxone on neonatal hypoxic-ischemic encephalopathy（HIE）.[Methods]91 cases were divided into two groups randomly. The cases in control group（45 cases）were given conventional therapy such as oxygen,and the cases in experimental group（46 cases）were given dopamine（5 ug/kg/min,ivgtt qd）,naloxone（0.1 mg/kg.d） and 10% glucose 30ml in the early stage on the basis of conventional therapy.[Results]Experimental group：31 cases（67.4%） were reacted,15 cases（32.6%） were in effect,and the effective power was 100%;controlled group：7 cases（15.6%） were reacted,26 cases（57.8%） were in effect,and the effective power was 73.3%. The effective power of the former was significantly higher than the latter （P﹤0.05）.[Conclusion]The therapy of low dosage injection of dopamine and naloxone is effective,economical and can reduce the fatality rate and improve the prognosis.