摘要
对Tangier病病因的研究,发现ATP结合盒转运蛋白A1(ATP binding cassette transport protein A1,ABCA1)在胆固醇逆向转运(reverse cholesterol transport,RCT)中起重要作用。ABCA1主要通过核受体PPARs途径发挥作用。ABCA1基因变异影响其功能。
During a study of the cause of Tangier disease it was discovered that ATP binding cassette transport protein A1 （ ABCA1 ） plays a key role in reverse cholesterol transport （ RCT）. ABCA1 performs a function in nuclear receptor PPAR pathway. The function of ABCA1 is influenced by the varieties of gene ABCA1.
出处
《心血管病学进展》
CAS
2007年第6期951-954,共4页
Advances in Cardiovascular Diseases
基金
四川省教育厅自然科学基金资助(2004A076)
