同型半胱氨酸与N-甲基-D-天冬氨酸受体的研究进展

Advances in Research into Relationship Between Homocysteine and N-methyl-D-aspartic Acid Receptor

同型半胱氨酸(homocysteine,Hcy)是心血管疾病的独立危险因子,作用机制涉及损伤血管功能、活化炎症细胞和血小板、促进凝血及心肌肥大等方面。N-甲基-D-天冬氨酸(N-methyl-D-aspartic acid,NMDA)受体是兴奋性氨基酸受体的一种亚型,传统观点认为其主要分布在中枢神经系统,在神经元回路的形成及学习、记忆过程中起关键作用,并与神经退行性疾病密切相关。近年来,NMDA受体在心血管疾病中的作用得到人们的关注。现就NMDA受体在Hcy致心血管细胞功能损伤中的作用方面的研究进展作一综述。

Homocysteine is an independent risk factor of cardiovascular disease. Its mechanism is involved in cardiovascular dysfunction, inflammatory cells and platelets activation, thrombin formation, and myocardial hypertrophia. N-methyl-D-aspartic acid receptor （ NMDAr） is one subtype of excitatory amino acid receptors. It has been accepted that NMDArs mainly present in the central nervous system, play pivotal roles during the production of neuron circuit, learning and memory, and are closely related to nervous retrograde disease. Recently, the roles of NMDArs in cardiovascular disease have attracted high levels of attention. This review describes the advances in understanding of the roles of NMDArs in homocysteine-induced cardiovascular dysfunction.