老年人广谱抗生素使用与肠道菌群失调的分析

Relationship between Antimicrobial Treatment and Imbalance of Intestinal Flora in the Elders

目的:探讨抗生素使用对老年人肠道菌群失调的影响。方法:以前瞻性和回顾性调查老年人抗生素使用程度和时间与菌群失调的关系以及基础疾病对菌群失调发生的影响。结果:广谱抗生素使用时间二周以上菌群失调率为54.76%,与使用一周以内者相比,有极显著性差异(P<0.01);三联抗生素联合使用菌群失调率为65.15%,与一联使用者相比,有极显著性差异(P<0.01);脑血管、肿瘤、呼吸系统疾病住院的病人菌群失调率显著高于其它系统疾病(P<0.05)。结论:老年人广谱抗生素使用的时间与多种联合应用是导致菌群失调的主要原因,基础疾病的影响亦不容忽视,对这一特殊人群必须用药全程监测,避免或减少菌群失调的发生。

Objective： To investigate the imbalance of intestinal flora caused by antimicrobial treatment in the elders.Methods：Old patients with antimicrobial treatment were observed;investigate adhibition of antimicrobial agents,the incidence of intestinal flora imbalance relation antibiotic in the elders.Results：The rate of intestinal flora imbalance was 54.76% in pations with two weeks antimicrobial application,higher than that in one week（P〈0.01）.The rate of intestinal flora imbalance was 65.15% in patients with three kinds of antimicrobial agents,higher than that in one kind（P〈0.01）.Conclusion：The overuse of antimicrobial agente can cause imbalance of intestinal flora.It is inimportemt to surgey the old patients of intestinal flora imbalance who receive antimicrobial.