联合检测尿微量白蛋白、β2微球蛋白对糖尿病早期肾损伤诊断的意义

Significance of combined detection of udnary albumin,i~ 2-microglobulin diabetes early diagnosis of renal injury

目的:通过检测糖尿病患者尿微量白蛋白(u-ALB)、β2微球蛋白(β2-M)的水平,探讨早期诊断糖尿病肾损伤的方法。方法:免疫透射比浊法检测尿微量白蛋白、微粒子酶免分析法检测β2微球蛋白。结果:尿蛋白阴性的糖尿病患者尿微量白蛋白结果(均值为66.42mg/L)、β2微球蛋白结果(均值为1.48mg/L)与正常对照组比较(均值分别为18.5mg/L、0.84mg/L)有显著性(P<0.01)。结论:联合检测尿微量白蛋白、β2微球蛋白对糖尿病早期肾损伤的诊断有重要意义。糖尿病患者应进行尿微量白蛋白、β2微球蛋白的筛查,可以有效地预防和监控糖尿病并发症的发生发展,提高阳性率,避免漏检。

Objective Through the detection of urinary microalbuminuria in diabetic patients （u-ALB）,β2-microglobulin levels, To study the early diagnosis of diabetic kidney injury method. Methods Immune transmission turbidity of urine microalbumin, Microparticle enzyme immunoassay detection of β2 -microglobulin. Results Urinary protein negative patients with diabetic microalbuminuria（average for 66.42 mg / L）, β2 -microglobulin（average for 1.48 mg / L） and normal control group （mean difference of 18.5 mg / L and 0.84 mg / L）） was significant （P〈0.01）.Conclusion Combined detection of microalbuminuria ,β2-microglobulin diabetes early diagnosis of renal injury in significance.Diabetic patients should be conducted urinary albumin, β2 microglobulin in the screening, can effectively prevent and control the occurrence and development of diabetic complications, the positive rate increased to avoid missed.